Functional specialization of the small interfering RNA pathway in response to virus infection.
In Drosophila, post-transcriptional gene silencing occurs when exogenous or endogenous double stranded RNA (dsRNA) is processed into small interfering RNAs (siRNAs) by Dicer-2 (Dcr-2) in association with a dsRNA-binding protein (dsRBP) cofactor called Loquacious (Loqs-PD).siRNAs are then loaded onto Argonaute-2 (Ago2) by the action of Dcr-2 with an